Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells

Humans with Wiskott-Aldrich syndrome display a progressive immunological disorder associated with compromised Wiskott-Aldrich Syndrome Interacting Protein (WIP) function. Mice deficient in WIP recapitulate such an immunodeficiency that has been attributed to T cell dysfunction; however, any contribu...

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Publicado no:Immunity
Main Authors: Keppler, Selina Jessica, Gasparrini, Francesca, Burbage, Marianne, Aggarwal, Shweta, Frederico, Bruno, Geha, Raif S., Way, Michael, Bruckbauer, Andreas, Batista, Facundo D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622935/
https://ncbi.nlm.nih.gov/pubmed/26453379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.09.004
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