The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses

Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin durin...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Keppler, Selina Jessica, Burbage, Marianne, Gasparrini, Francesca, Hartjes, Lara, Aggarwal, Shweta, Massaad, Michel J., Geha, Raif S., Bruckbauer, Andreas, Batista, Facundo D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077251/
https://ncbi.nlm.nih.gov/pubmed/30021160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.051
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