A WIP peptide restores WASP levels and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding

BACKGROUND: The Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) are caused by mutations in WAS, which encodes for WAS protein (WASP). The WASP-interacting protein (WIP) stabilizes WASP, as evidenced by severely decreased WASP levels in T cells from WIP-deficient mice. The majority...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Massaad, Michel J., Ramesh, Narayanaswamy, Bras, Severine Le, Giliani, Silvia, Notarangelo, Lucia D., Al-Herz, Waleed, Notarangelo, Luigi D., Geha, Raif S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077682/
https://ncbi.nlm.nih.gov/pubmed/21376381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.01.015
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller