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A WIP peptide restores WASP levels and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding

BACKGROUND: The Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) are caused by mutations in WAS, which encodes for WAS protein (WASP). The WASP-interacting protein (WIP) stabilizes WASP, as evidenced by severely decreased WASP levels in T cells from WIP-deficient mice. The majority...

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書誌詳細
主要な著者: Massaad, Michel J., Ramesh, Narayanaswamy, Bras, Severine Le, Giliani, Silvia, Notarangelo, Lucia D., Al-Herz, Waleed, Notarangelo, Luigi D., Geha, Raif S.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077682/
https://ncbi.nlm.nih.gov/pubmed/21376381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.01.015
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