Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

Neutral sphingomyelinase (nSMase) activation in response to environmental stress or inflammatory cytokine stimuli generates the second messenger ceramide, which mediates the stress-induced apoptosis. However, the signaling pathways and activation mechanism underlying this process have yet to be eluc...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Yabu, T, Shiba, H, Shibasaki, Y, Nakanishi, T, Imamura, S, Touhata, K, Yamashita, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291487/
https://ncbi.nlm.nih.gov/pubmed/25168245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.128
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