Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

BACKGROUND: Ceramide accumulation is considered a contributing factor to neuronal dysfunction and damage. However, the underlying mechanisms that occur following ischemic insult are still unclear. METHODS: In the present study, we established cerebral ischemia models using four-vessel occlusion and...

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Autores principales: Gu, LiZe, Huang, BaoSheng, Shen, Wei, Gao, Li, Ding, ZhengZheng, Wu, HuiWen, Guo, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844623/
https://ncbi.nlm.nih.gov/pubmed/24007266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-109
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