Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

Neutral sphingomyelinase (nSMase) activation in response to environmental stress or inflammatory cytokine stimuli generates the second messenger ceramide, which mediates the stress-induced apoptosis. However, the signaling pathways and activation mechanism underlying this process have yet to be eluc...

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Vydáno v:Cell Death Differ
Hlavní autoři: Yabu, T, Shiba, H, Shibasaki, Y, Nakanishi, T, Imamura, S, Touhata, K, Yamashita, M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291487/
https://ncbi.nlm.nih.gov/pubmed/25168245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.128
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