Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene) is a key enzyme for ceramide generation that is involved in regulating cellular stress responses and exosome-mediated intercellular communication. nSMase2 is activated by diverse stimuli, including the anionic phospholipid phosphatidyls...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Airola, Michael V., Shanbhogue, Prajna, Shamseddine, Achraf A., Guja, Kip E., Senkal, Can E., Maini, Rohan, Bartke, Nana, Wu, Bill X., Obeid, Lina M., Garcia-Diaz, Miguel, Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514751/
https://ncbi.nlm.nih.gov/pubmed/28652336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705134114
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