nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe(−/−) Mice

OBJECTIVE—: Atherosclerosis is a chronic multifactorial and inflammatory disease of large and medium arteries and the leading cause of cardiovascular diseases worldwide. The aim of this study was to investigate whether and how the nSMase2 (type 2-neutral sphingomyelinase), a key enzyme of sphingolip...

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Bibliographic Details
Published in:Arterioscler Thromb Vasc Biol
Main Authors: Lallemand, Tom, Rouahi, Myriam, Swiader, Audrey, Grazide, Marie-Hélène, Geoffre, Nancy, Alayrac, Paul, Recazens, Emeline, Coste, Agnès, Salvayre, Robert, Nègre-Salvayre, Anne, Augé, Nathalie
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2018
Subjects:
Basic Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039418/
https://ncbi.nlm.nih.gov/pubmed/29794115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311208
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