nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe(−/−) Mice

OBJECTIVE—: Atherosclerosis is a chronic multifactorial and inflammatory disease of large and medium arteries and the leading cause of cardiovascular diseases worldwide. The aim of this study was to investigate whether and how the nSMase2 (type 2-neutral sphingomyelinase), a key enzyme of sphingolip...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Lallemand, Tom, Rouahi, Myriam, Swiader, Audrey, Grazide, Marie-Hélène, Geoffre, Nancy, Alayrac, Paul, Recazens, Emeline, Coste, Agnès, Salvayre, Robert, Nègre-Salvayre, Anne, Augé, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039418/
https://ncbi.nlm.nih.gov/pubmed/29794115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311208
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