Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability

OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activity despite being located outside the active site. Th...

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Vydáno v:J Antimicrob Chemother
Hlavní autoři: Makena, Anne, Brem, Jürgen, Pfeffer, Inga, Geffen, Rebecca E. J., Wilkins, Sarah E., Tarhonskaya, Hanna, Flashman, Emily, Phee, Lynette M., Wareham, David W., Schofield, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291237/
https://ncbi.nlm.nih.gov/pubmed/25324420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku403
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