Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability

OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activity despite being located outside the active site. Th...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Antimicrob Chemother
Auteurs principaux: Makena, Anne, Brem, Jürgen, Pfeffer, Inga, Geffen, Rebecca E. J., Wilkins, Sarah E., Tarhonskaya, Hanna, Flashman, Emily, Phee, Lynette M., Wareham, David W., Schofield, Christopher J.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291237/
https://ncbi.nlm.nih.gov/pubmed/25324420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku403
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