Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability

OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activity despite being located outside the active site. Th...

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Detalles Bibliográficos
Publicado en:J Antimicrob Chemother
Main Authors: Makena, Anne, Brem, Jürgen, Pfeffer, Inga, Geffen, Rebecca E. J., Wilkins, Sarah E., Tarhonskaya, Hanna, Flashman, Emily, Phee, Lynette M., Wareham, David W., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291237/
https://ncbi.nlm.nih.gov/pubmed/25324420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku403
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