Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability

OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activity despite being located outside the active site. Th...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Antimicrob Chemother
Autori principali: Makena, Anne, Brem, Jürgen, Pfeffer, Inga, Geffen, Rebecca E. J., Wilkins, Sarah E., Tarhonskaya, Hanna, Flashman, Emily, Phee, Lynette M., Wareham, David W., Schofield, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291237/
https://ncbi.nlm.nih.gov/pubmed/25324420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku403
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi