MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

We propose the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) method for prioritizing single-guide RNAs, genes and pathways in genome-scale CRISPR/Cas9 knockout screens. MAGeCK demonstrates better performance compared with existing methods, identifies both positively and negativel...

Full description

Saved in:

Bibliographic Details
Published in:	Genome Biol
Main Authors:	Li, Wei, Xu, Han, Xiao, Tengfei, Cong, Le, Love, Michael I, Zhang, Feng, Irizarry, Rafael A, Liu, Jun S, Brown, Myles, Liu, X Shirley
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2014
Subjects:	Method
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4290824/ https://ncbi.nlm.nih.gov/pubmed/25476604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0554-4
Tags:	Add Tag No Tags, Be the first to tag this record!

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Similar Items