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MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
We propose the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) method for prioritizing single-guide RNAs, genes and pathways in genome-scale CRISPR/Cas9 knockout screens. MAGeCK demonstrates better performance compared with existing methods, identifies both positively and negativel...
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Publicado no: | Genome Biol |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4290824/ https://ncbi.nlm.nih.gov/pubmed/25476604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0554-4 |
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