Improved design and analysis of CRISPR knockout screens

MOTIVATION: Genome-wide clustered, regularly interspaced, short palindromic repeat (CRISPR)-Cas9 screen has been widely used to interrogate gene functions. However, the rules to design better libraries beg further refinement. RESULTS: We found single guide RNA (sgRNA) outliers are characterized by h...

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Enregistré dans:
Détails bibliographiques
Publié dans:Bioinformatics
Auteurs principaux: Chen, Chen-Hao, Xiao, Tengfei, Xu, Han, Jiang, Peng, Meyer, Clifford A, Li, Wei, Brown, Myles, Liu, X Shirley
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Original Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247926/
https://ncbi.nlm.nih.gov/pubmed/29868757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty450
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