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Improved design and analysis of CRISPR knockout screens
MOTIVATION: Genome-wide clustered, regularly interspaced, short palindromic repeat (CRISPR)-Cas9 screen has been widely used to interrogate gene functions. However, the rules to design better libraries beg further refinement. RESULTS: We found single guide RNA (sgRNA) outliers are characterized by h...
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| Опубликовано в: : | Bioinformatics |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6247926/ https://ncbi.nlm.nih.gov/pubmed/29868757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty450 |
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