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CRISPR/Cas9-deaminase enables robust base editing in Rhodobacter sphaeroides 2.4.1

BACKGROUND: CRISPR/Cas9 systems have been repurposed as canonical genome editing tools in a variety of species, but no application for the model strain Rhodobacter sphaeroides 2.4.1 was unveiled. RESULTS: Here we showed two kinds of programmable base editing systems, cytosine base editors (CBEs) and...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Luo, Yufeng, Ge, Mei, Wang, Bolun, Sun, Changhong, Wang, Junyi, Dong, Yuyang, Xi, Jianzhong Jeff
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183636/
https://ncbi.nlm.nih.gov/pubmed/32334589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-01345-w
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