Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.

Ítems similars

• C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
  per: Tanaka, S, et al.
  Publicat: (1994)
• Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
  per: Gotoh, N, et al.
  Publicat: (1997)
• Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
  per: Batzer, A G, et al.
  Publicat: (1994)
• A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3.
  per: Gotoh, N, et al.
  Publicat: (1996)
• Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.
  per: Ravichandran, K S, et al.
  Publicat: (1995)