Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
The mammalian shc gene encodes two overlapping proteins of 46 and 52 kDa, each with a C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence, that induce malignant transformation when overexpressed in mouse fibroblasts. p46shc, p52shc, and an additional 66-kDa shc gen...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1992
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1409579/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.19.8869 |
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