Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

The mammalian shc gene encodes two overlapping proteins of 46 and 52 kDa, each with a C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence, that induce malignant transformation when overexpressed in mouse fibroblasts. p46shc, p52shc, and an additional 66-kDa shc gen...

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Hlavní autoři: McGlade, J, Cheng, A, Pelicci, G, Pelicci, P G, Pawson, T
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC50025/
https://ncbi.nlm.nih.gov/pubmed/1409579
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