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Mitogen-Inducible Gene 6 Inhibits Angiogenesis by Binding to SHC1 and Suppressing Its Phosphorylation

The mitogen-inducible gene 6 (MIG6) is an adaptor protein widely expressed in vascular endothelial cells. However, it remains unknown thus far whether it plays a role in angiogenesis. Here, using comprehensive in vitro and in vivo model systems, we unveil a potent anti-angiogenic effect of MIG6 in r...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Lixian Liu, Liying Xing, Rongyuan Chen, Jianing Zhang, Yuye Huang, Lijuan Huang, Bingbing Xie, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Xianchai Lin, Anil Kumar, Jong Kyong Kim, Chunsik Lee, Xuri Li
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2021-02-01
Rangatū:Frontiers in Cell and Developmental Biology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fcell.2021.634242/full
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