Mitogen-Inducible Gene 6 Inhibits Angiogenesis by Binding to SHC1 and Suppressing Its Phosphorylation

The mitogen-inducible gene 6 (MIG6) is an adaptor protein widely expressed in vascular endothelial cells. However, it remains unknown thus far whether it plays a role in angiogenesis. Here, using comprehensive in vitro and in vivo model systems, we unveil a potent anti-angiogenic effect of MIG6 in r...

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Autors principals:	Lixian Liu, Liying Xing, Rongyuan Chen, Jianing Zhang, Yuye Huang, Lijuan Huang, Bingbing Xie, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Xianchai Lin, Anil Kumar, Jong Kyong Kim, Chunsik Lee, Xuri Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-02-01
Col·lecció:	Frontiers in Cell and Developmental Biology
Matèries:	MIG6 angiogenesis SHC1 endothelial cell ocular neovascularization
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcell.2021.634242/full
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