Mitogen-Inducible Gene 6 Inhibits Angiogenesis by Binding to SHC1 and Suppressing Its Phosphorylation

The mitogen-inducible gene 6 (MIG6) is an adaptor protein widely expressed in vascular endothelial cells. However, it remains unknown thus far whether it plays a role in angiogenesis. Here, using comprehensive in vitro and in vivo model systems, we unveil a potent anti-angiogenic effect of MIG6 in r...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Lixian Liu, Liying Xing, Rongyuan Chen, Jianing Zhang, Yuye Huang, Lijuan Huang, Bingbing Xie, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Xianchai Lin, Anil Kumar, Jong Kyong Kim, Chunsik Lee, Xuri Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-02-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	MIG6 angiogenesis SHC1 endothelial cell ocular neovascularization
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2021.634242/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!