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Inhibition of [(14)C]Chloramphenicol Binding to Escherichia coli Ribosomes by Erythromycin Derivatives

The effect of erythromycin A and 35 analogues of erythromycin A on [(14)C]chloramphenicol binding to Escherichia coli ribosomes was evaluated. Substitutions on various portions of the erythromycin molecule were made with retention of ability to bind to ribosomes. Specifically, substantial activity i...

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Bibliographic Details
Main Authors: Pestka, Sidney, LeMahieu, Ronald A.
Format: Artigo
Language:Inglês
Published: 1974
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC429045/
https://ncbi.nlm.nih.gov/pubmed/15828169
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