Induction of the CTLA-4 Gene in Human Lymphocytes Is Dependent on NFAT Binding the Proximal Promoter()

CTLA-4 is a member of the costimulatory family, has homology to CD28, and binds the B7 family of ligands. Unlike CD28, CTLA-4 ligation transmits a negative signal in T cells. CTLA-4 expression, while inducible in most T cells, is expressed constitutively on T cells with a regulatory phenotype. The m...

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Bibliografiska uppgifter
I publikationen:J Immunol
Huvudupphovsmän: Gibson, Heather M., Hedgcock, Carrie J., Aufiero, Barbara M., Wilson, Adam J., Hafner, Mikehl S., Tsokos, George C., Wong, Henry K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290020/
https://ncbi.nlm.nih.gov/pubmed/17785820
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