Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells

Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansio...

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Main Authors: Doyle, Alden M., Mullen, Alan C., Villarino, Alejandro V., Hutchins, Anne S., High, Frances A., Lee, Hubert W., Thompson, Craig B., Reiner, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193479/
https://ncbi.nlm.nih.gov/pubmed/11581312
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