Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells

Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansio...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Doyle, Alden M., Mullen, Alan C., Villarino, Alejandro V., Hutchins, Anne S., High, Frances A., Lee, Hubert W., Thompson, Craig B., Reiner, Steven L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2001
Soggetti:
Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193479/
https://ncbi.nlm.nih.gov/pubmed/11581312
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi