CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation

The blockade of inhibitory receptors such as CTLA-4 (CD152) is being used as immune-checkpoint therapy, offering a powerful strategy to restore effective immune responses against tumors. To determine signal components that are induced under the control of CTLA-4 we analyzed activated murine CD8(+) T...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Lingel, Holger, Wissing, Josef, Arra, Aditya, Schanze, Denny, Lienenklaus, Stefan, Klawonn, Frank, Pierau, Mandy, Zenker, Martin, Jänsch, Lothar, Brunner-Weinzierl, Monika C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596418/
https://ncbi.nlm.nih.gov/pubmed/28644433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.102
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