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Differential CTLA-4 expression in human CD4(+) versus CD8(+) T cells is associated with increased NFAT1 and inhibition of CD4(+) proliferation
CTLA-4 is a costimulatory molecule that negatively regulates T cell activation. Originally identified in murine CD8(+) T cells, it has been found to be rapidly induced on human T cells. Furthermore, CTLA-4 is expressed on regulatory T cells (T(regs)). Clinically, targeting CTLA-4 has clinical utilit...
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| Publicado no: | Genes Immun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4284071/ https://ncbi.nlm.nih.gov/pubmed/24173147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2013.57 |
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