Differential CTLA-4 expression in human CD4(+) versus CD8(+) T cells is associated with increased NFAT1 and inhibition of CD4(+) proliferation

CTLA-4 is a costimulatory molecule that negatively regulates T cell activation. Originally identified in murine CD8(+) T cells, it has been found to be rapidly induced on human T cells. Furthermore, CTLA-4 is expressed on regulatory T cells (T(regs)). Clinically, targeting CTLA-4 has clinical utilit...

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Publicado en:Genes Immun
Autores principales: Chan, Derek V., Gibson, Heather M., Aufiero, Barbara M., Wilson, Adam J., Hafner, Mikehl S., Mi, Qing-Sheng, Wong, Henry K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284071/
https://ncbi.nlm.nih.gov/pubmed/24173147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2013.57
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