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CTLA-4 is Required by CD4(+)CD25(+) Treg to Control CD4(+) T Cell Lymphopenia-Induced Proliferation

CTLA-4 is constitutively expressed by CD4+CD25+Foxp3+ regulatory T cells (Treg) but its precise role in Treg function is not clear. Although blockade of CTLA-4 interferes with Treg function, studies using CTLA-4 deficient Treg have failed to reveal an essential requirement for CTLA-4 in Treg suppres...

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Bibliografiske detaljer
Main Authors: Sojka, Dorothy K., Hughson, Angela, Fowell, Deborah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835300/
https://ncbi.nlm.nih.gov/pubmed/19462377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838603
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