Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes

OBJECTIVE: The mechanistic basis for the breakdown of T-cell tolerance in type 1 diabetes is unclear and could result from a gain of effector function and/or loss of regulatory function. In humans, the CD4+CD25+Foxp3+ T–cell compartment contains both effector and regulatory T cells, and it is not kn...

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Hlavní autoři: Hughson, Angela, Bromberg, Irina, Johnson, Barbara, Quataert, Sally, Jospe, Nicholas, Fowell, Deborah J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142074/
https://ncbi.nlm.nih.gov/pubmed/21715555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1661
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