Low frequency of CD4(+)CD25(+ )Treg in SLE patients: a heritable trait associated with CTLA4 and TGFβ gene variants

BACKGROUND: CD4(+)CD25(+ )regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE),...

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Detalhes bibliográficos
Principais autores: Barreto, Marta, Ferreira, Ricardo C, Lourenço, Lara, Moraes-Fontes, Maria F, Santos, Eugénia, Alves, Miguel, Carvalho, Cláudia, Martins, Berta, Andreia, Rita, Viana, João F, Vasconcelos, Carlos, Mota-Vieira, Luísa, Ferreira, Carlos, Demengeot, Jocelyne, Vicente, Astrid M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656467/
https://ncbi.nlm.nih.gov/pubmed/19173720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-10-5
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