Low frequency of CD4(+)CD25(+ )Treg in SLE patients: a heritable trait associated with CTLA4 and TGFβ gene variants

BACKGROUND: CD4(+)CD25(+ )regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE),...

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Hlavní autoři: Barreto, Marta, Ferreira, Ricardo C, Lourenço, Lara, Moraes-Fontes, Maria F, Santos, Eugénia, Alves, Miguel, Carvalho, Cláudia, Martins, Berta, Andreia, Rita, Viana, João F, Vasconcelos, Carlos, Mota-Vieira, Luísa, Ferreira, Carlos, Demengeot, Jocelyne, Vicente, Astrid M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656467/
https://ncbi.nlm.nih.gov/pubmed/19173720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-10-5
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