Impaired proteasome function activates GATA3 in T-cells and upregulates CTLA-4: relevance for Sezary syndrome

Highly regulated expression of the negative co-stimulatory molecule CTLA-4 on T-cells modulates T-cell activation and proliferation. CTLA-4 is preferentially expressed in Th2 T-cells, whose differentiation depends on the transcriptional regulator GATA3. Sezary syndrome (SS) is a T-cell malignancy ch...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Gibson, Heather M., Mishra, Anjali, Chan, Derek V., Hake, Timothy S., Porcu, Pierluigi, Wong, Henry K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284066/
https://ncbi.nlm.nih.gov/pubmed/22951729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.265
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