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Promoter Methylation Regulates SAMHD1 Gene Expression in Human CD4(+) T Cells

The retrovirus restriction factor SAMHD1 is the first identified mammalian dNTP triphosphohydrolase that is highly expressed in human myeloid lineage cells and CD4(+) T lymphocytes. Although SAMHD1 expression is variable in human cell lines and tissue types, mechanisms underlying SAMHD1 gene regulat...

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Main Authors: de Silva, Suresh, Hoy, Heather, Hake, Timothy S., Wong, Henry K., Porcu, Pierluigi, Wu, Li
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610999/
https://ncbi.nlm.nih.gov/pubmed/23426363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.447201
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