SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4(+) T-lymphocytes cannot be upregulated by interferons

BACKGROUND: SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4(+) T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4(+) T-...

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Hauptverfasser: St Gelais, Corine, de Silva, Suresh, Amie, Sarah M, Coleman, Christopher M, Hoy, Heather, Hollenbaugh, Joseph A, Kim, Baek, Wu, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527137/
https://ncbi.nlm.nih.gov/pubmed/23231760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-105
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