Molecular Basis for the Selective Toxicity of Amphotericin B for Yeast and Filipin for Animal Cells

Among the polyene antibiotics, many, like filipin, cannot be used clinically because they are toxic; amphotericin B, however, is useful in therapy of human fungal infections because it is less toxic. Both the toxicity of filipin and the therapeutic value of amphotericin B can be rationalized at the...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Kotler-Brajtburg, Janina, Price, H. D., Medoff, Gerald, Schlessinger, David, Kobayashi, George S.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1974
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC428978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15825391/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.5.4.377
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