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Molecular Basis for the Selective Toxicity of Amphotericin B for Yeast and Filipin for Animal Cells

Among the polyene antibiotics, many, like filipin, cannot be used clinically because they are toxic; amphotericin B, however, is useful in therapy of human fungal infections because it is less toxic. Both the toxicity of filipin and the therapeutic value of amphotericin B can be rationalized at the...

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Detalhes bibliográficos
Main Authors: Kotler-Brajtburg, Janina, Price, H. D., Medoff, Gerald, Schlessinger, David, Kobayashi, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: 1974
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC428978/
https://ncbi.nlm.nih.gov/pubmed/15825391
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