Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis

Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues are poorly understood. Here, we demonstrate that Gli1 marks perivascular MSC-like cells that substantially contribute to organ fibrosis. In v...

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Publicat a:Cell Stem Cell
Autors principals: Kramann, Rafael, Schneider, Rebekka K., DiRocco, Derek P., Machado, Flavia, Fleig, Susanne, Bondzie, Philip A., Henderson, Joel M., Ebert, Benjamin L., Humphreys, Benjamin D.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289444/
https://ncbi.nlm.nih.gov/pubmed/25465115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.11.004
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