Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), induces formation of granulomas, structures in which immune cells and bacteria colocalize. Macrophages are among the most abundant cell types in granulomas and have been shown to serve as both critical bactericidal cells and targe...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Marino, Simeone, Cilfone, Nicholas A., Mattila, Joshua T., Linderman, Jennifer J., Flynn, JoAnne L., Kirschner, Denise E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288886/
https://ncbi.nlm.nih.gov/pubmed/25368116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02494-14
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