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Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate
The immunogenicity of biotherapeutics can bottleneck development pipelines and poses a barrier to widespread clinical application. As a result, there is a growing need for improved deimmunization technologies. We have recently described algorithms that simultaneously optimize proteins for both reduc...
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| Publié dans: | PLoS Comput Biol |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4288714/ https://ncbi.nlm.nih.gov/pubmed/25568954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003988 |
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