On-target off-tumor toxicity; when enhancing an NKG2D-based CAR in vitro led to severe toxicities in vivo

Lignende værker

• T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice
  af: VanSeggelen, Heather, et al.
  Udgivet: (2015)
• Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
  af: Hammill, Joanne A., et al.
  Udgivet: (2015)
• Chimeric antigen receptor–engineered T cells as oncolytic virus carriers
  af: VanSeggelen, Heather, et al.
  Udgivet: (2015)
• A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity
  af: Hammill, Joanne A., et al.
  Udgivet: (2020)
• Combined mTOR Inhibition and OX40 Agonism Enhances CD8(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines
  af: Bassett, Jennifer D, et al.
  Udgivet: (2012)