A novel RNA molecular signature for activation of 2′-5′ oligoadenylate synthetase-1

Human 2′-5′ oligoadenylate synthetase-1 (OAS1) is central in innate immune system detection of cytoplasmic double-stranded RNA (dsRNA) and promotion of host antiviral responses. However, the molecular signatures that promote OAS1 activation are currently poorly defined. We show that the 3′-end polyu...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Vachon, Virginia K., Calderon, Brenda M., Conn, Graeme L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288181/
https://ncbi.nlm.nih.gov/pubmed/25477390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1289
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