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A human cellular noncoding RNA activates the antiviral protein 2′–5′-oligoadenylate synthetase 1
The 2′–5′-oligoadenylate synthetase (OAS) family of enzymes sense cytosolic dsRNA, a potent signal of viral infection. In response to dsRNA binding, OAS proteins synthesize the second messenger 2′–5′-linked oligoadenylate that activates the latent ribonuclease L (RNase L). RNase L–mediated degradati...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6187638/ https://ncbi.nlm.nih.gov/pubmed/30126839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004747 |
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