A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF

Human immunodeficiency virus type − 1 (HIV-1) protease, a homodimeric aspartyl protease, is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS. Multidrug-resistant (MDR) clinical isolate-769 HIV-1 protease (PDB ID: 3PJ6) has been shown to exhibit expanded active site cavity...

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Bibliographic Details
Published in:J Mol Graph Model
Main Authors: Yedidi, Ravikiran S., Proteasa, Gheorghe, Martin, Philip D., Liu, Zhigang, Vickrey, John F., Kovari, Iulia A., Kovari, Ladislau C.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287366/
https://ncbi.nlm.nih.gov/pubmed/25108107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2014.06.010
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