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Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin
We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<50 μM); this effect was observed in multiple types of human xenograft tumors in vitro and in vivo. Clinical evaluation of noncytotoxic suramin is ongoing. Because (a) suramin inhibits reverse transcriptase,...
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| 出版年: | AAPS J |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer US
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4287294/ https://ncbi.nlm.nih.gov/pubmed/25425294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9703-7 |
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