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Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin
We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<50 μM); this effect was observed in multiple types of human xenograft tumors in vitro and in vivo. Clinical evaluation of noncytotoxic suramin is ongoing. Because (a) suramin inhibits reverse transcriptase,...
Guardat en:
| Publicat a: | AAPS J |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer US
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4287294/ https://ncbi.nlm.nih.gov/pubmed/25425294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9703-7 |
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