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SETting OP449 into the PP2A-Activating-Drug family
The PP2A tumor suppressor is inactivated in different leukemias through the activity of its endogenous inhibitors (e.g. SET), which are aberrantly regulated by oncogenic tyrosine kinases. Like other effective and non-toxic PP2A-activating-drugs (PADs), OP449 inhibits SET and impairs leukemogenesis....
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| Veröffentlicht in: | Clin Cancer Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4286336/ https://ncbi.nlm.nih.gov/pubmed/24634375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0166 |
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