Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcome drug resistance in myeloid leukemia

PURPOSE: The SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A), is overexpressed in leukemia. We evaluated the efficacy of SET antagonism in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) cell lines, a murine leukemia model, and primary patient samples using O...

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Detalhes bibliográficos
Main Authors: Agarwal, Anupriya, MacKenzie, Ryan J., Pippa, Raffaella, Eide, Christopher A., Oddo, Jessica, Tyner, Jeffrey W., Sears, Rosalie, Vitek, Michael P., Odero, María D., Christensen, Dale, Druker, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989420/
https://ncbi.nlm.nih.gov/pubmed/24436473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2575
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