Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247

Humanized monoclonal antibody KD-247 targets the Gly(312)-Pro(313)-Gly(314)-Arg(315) arch of the third hypervariable (V3) loop of the HIV-1 surface glycoprotein. It potently neutralizes many HIV-1 clade B isolates, but not of other clades. To understand the molecular basis of this specificity, we so...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Kirby, Karen A., Ong, Yee Tsuey, Hachiya, Atsuko, Laughlin, Thomas G., Chiang, Leslie A., Pan, Yun, Moran, Jennifer L., Marchand, Bruno, Singh, Kamalendra, Gallazzi, Fabio, Quinn, Thomas P., Yoshimura, Kazuhisa, Murakami, Toshio, Matsushita, Shuzo, Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285544/
https://ncbi.nlm.nih.gov/pubmed/25351987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-252262
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados