Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247

Humanized monoclonal antibody KD-247 targets the Gly(312)-Pro(313)-Gly(314)-Arg(315) arch of the third hypervariable (V3) loop of the HIV-1 surface glycoprotein. It potently neutralizes many HIV-1 clade B isolates, but not of other clades. To understand the molecular basis of this specificity, we so...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Kirby, Karen A., Ong, Yee Tsuey, Hachiya, Atsuko, Laughlin, Thomas G., Chiang, Leslie A., Pan, Yun, Moran, Jennifer L., Marchand, Bruno, Singh, Kamalendra, Gallazzi, Fabio, Quinn, Thomas P., Yoshimura, Kazuhisa, Murakami, Toshio, Matsushita, Shuzo, Sarafianos, Stefan G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2015
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285544/
https://ncbi.nlm.nih.gov/pubmed/25351987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-252262
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares