Preparation of Biologically Active Single-Chain Variable Antibody Fragments that Target the HIV-1 gp120 V3 Loop

KD-247 is a humanized monoclonal antibody that targets the third hypervariable (V3) loop of gp120. It can efficiently neutralize a broad panel of clade B, but not non-clade B, HIV-1 isolates. To overcome this limitation, we are seeking to prepare genetically-engineered single-chain variable fragment...

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Main Authors: Ong, Y.T., Kirby, K.A., Hachiya, A., Chiang, L.A., Marchand, B., Yoshimura, K., Murakami, T., Singh, K., Matsushita, S., Sarafianos, S.G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612353/
https://ncbi.nlm.nih.gov/pubmed/23273194
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